innobationbio

Technology

MALDI-TOF MS (Matrix-assisted Laser Desorption/Ionization Time-Of-Flight Mass spectrometry) is useful for analysis of DNA, protein, peptide and sugar and typing of microorganism typing. Pulsed laser irradiates crystal mixture containing matrix and sample / the analyte molecules in samples are ionized by being protonated or deprotonated in the hot plume of ablated gases. Finally, mass of the analyte molecules can be calculated by TOF

It is capable of broad mass detection range / high resolution / high speed for sample analysis. Soft ionization that involves a laser striking a matrix of small molecules to make the analyte molecules into the gas phase without fragmenting or decomposing them. MALDI-TOF MS can be a powerful tool to translate the analytic results.

Principle of MALDI-TOF MS

Cancer Screening biomarker

InnoBation Bio has several IPs and original technology for “Parylene Chip” MALDI-TOF MS target plate. Disposable MALDI-TOF parylene chip target plate for quantification and qualification of low mass biomaterials, overcomes critical limitation of MALDI-TOF MS. Parylene coating prevents the reaching of matrix ions the detector which decreases noise peaks in less than 1000 m/z, enables to analyze and quantify various low mass biomaterials including all test compounds in the laboratory medicine (ex. Immune suppressant), and may replace LC-MS for pharmacokinetics (PK) in the laboratory medicine. MALDI-TOF parylene chip target plate will be also useful for disease screening including cancer, infectious disease etc.

Parylene Chip Plate VS Previous Plate

Previous Plate